Androgen receptor polyglutamine repeat length affects receptor activity and C2C12 cell development
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منابع مشابه
Androgen receptor polyglutamine repeat length affects receptor activity and C2C12 cell development.
Testosterone (T) has an anabolic effect on skeletal muscle and is believed to exert its local effects via the androgen receptor (AR). The AR harbors a polymorphic stretch of glutamine repeats demonstrated to inversely affect receptor transcriptional activity in prostate and kidney cells. The effects of AR glutamine repeat length on skeletal muscle are unknown. In this study we examined the effe...
متن کاملAndrogen Receptor Polyglutamine Repeat Length Affects Receptor Activity and C2c12 Cell Myogenic Potential
Title of Document: ANDROGEN RECEPTOR POLYGLUTAMINE REPEAT LENGTH AFFECTS RECEPTOR ACTIVITY AND C2C12 CELL MYOGENIC POTENTIAL
متن کاملCALL FOR PAPERS Functional Analysis of Sequence Variation Androgen receptor polyglutamine repeat length affects receptor activity and C2C12 cell development
Sheppard RL, Spangenburg EE, Chin ER, Roth SM. Androgen receptor polyglutamine repeat length affects receptor activity and C2C12 cell development. Physiol Genomics 43: 1135–1143, 2011. First published August 9, 2011; doi:10.1152/physiolgenomics.00049.2011.—Testosterone (T) has an anabolic effect on skeletal muscle and is believed to exert its local effects via the androgen receptor (AR). The AR...
متن کاملAssessment of Correlation between Androgen Receptor CAG Repeat Length and Infertility in Infertile Men Living in Khuzestan, Iran
Background The androgen receptor (AR) gene contains a polymorphic trinucleotide repeat that encodes a polyglutamine tract in its N-terminal transactivation domain (NTAD). We aimed to find a correlation between the length of this polymorphic tract and azoospermia or oligozoospermia in infertile men living in Khuzestan, Iran. MaterialsAndMethods In this case-control study during two years till 20...
متن کاملassociation of androgen receptor ggn repeat length polymorphism and male infertility in khuzestan, iran
background: androgens play critical role in secondary sexual and male gonads differentiations such as spermatogenesis, via androgen receptor. the human androgen receptor (ar) encoding gene contains two regions with three nucleotide polymorphic repeats (cag and ggn) in the first exon. unlike the cag repeats, the ggn has been less studied because of technical difficulties, so the functional role ...
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ژورنال
عنوان ژورنال: Physiological Genomics
سال: 2011
ISSN: 1094-8341,1531-2267
DOI: 10.1152/physiolgenomics.00049.2011